![]() The present prospective study was performed at theĬhildren's Hospital of Zhejiang University School of Medicine Present study was the first to perform this assessment. The correlation between MPV/PLT and liver function Investigate the ability of MPV/PLT to detect IM in pediatric ( 13, 14), its utility in pediatric patients with Index for the diagnosis of numerous diseases in adult patients Was more common than elevation of bilirubin ( 12).Īlthough the MPV/PLT ratio is known to be a useful Indicated that elevation of alanine aminotransferase (ALT),Īspartate aminotransferase (AST) and γ-glutamyl transferase (GGT) Hepatic dysfunction is common in IM patients. Simple biomarker of inflammation and is increased in cardiovascularĭiseases, peripheral diseases and diabetes mellitus ( 9– 11). The mean platelet volume (MPV), as an indicator of platelets, is a Hepatosplenomegaly and the enlargement of the spleen is highlyĬorrelated with the platelet count (PLT) in the peripheral blood. Usually occurs during the onset or end of the disease and lasts forġ–6 days ( 7, 8). It is characterized by fever, pharyngitis, It usually affects pediatric, adolescent and Infectious mononucleosis (IM) is a typical form of The viral genes with the ability to evade the host's immune Infection may lead to downregulation of the expression of most of Infection in the circulating memory B cells ( 4, 5). Oropharyngeal lymphoid tissues and then establishes a persistent Range of lymphoid and epithelial malignancies and autoimmuneĭiseases ( 2, 3). >95% of the population worldwide, is a human γ-1 herpes virus In conclusion, the MPV/PLT ratio may be a novel diagnostic indicator for pediatric IM and indirectly predict damage to liver function.Įpstein-Barr virus (EBV), which is carried in In the receiver operating characteristic analysis, a sensitivity of 83.7% and specificity of 76.0% regarding the prediction of IM in pediatric patients using the MPV/PLT ratio was achieved at the cutoff of MPV/PLT(%)=3.42. ![]() Furthermore, MPV/PLT was positively correlated with ALT, AST, GGT, UA and TC (P≤0.01). Regression analysis under stepwise adjustment indicated that PLT and MPV/PLT were significantly associated with IM (P<0.01). WBC, ALT, AST, GGT, UA, TG, MPV and the MPV/PLT ratio in the patients were significantly higher compared with those in the controls (P<0.01), while RBC, HB, urea, TC, PLT and PDW were significantly lower in the patients (P<0.05 for PDW and P<0.01 for others). The white blood cell count (WBC), red blood cell count (RBC), hemoglobin (HB), platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ‑glutamyl transferase (GGT), uric acid (UA), urea, creatinine, total cholesterol (TC) and triglycerides (TG) in peripheral blood were evaluated. In the present prospective study, a total of 141 pediatric patients with IM and 146 healthy subjects were enrolled. The aim of the present study was to provide novel laboratory indexes for infectious mononucleosis (IM) in pediatric patients.
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